Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist

AIMS: To assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of intranasal SB-705498, a selective TRPV1 antagonist. METHODS: Two randomized, double-blind, placebo-controlled, clinical studies were performed: (i) an intranasal SB-705498 first time in human study to examin...

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Autori principali: Holland, Carlijn, Drunen, Cornelis Van, Denyer, Jane, Smart, Kevin, Segboer, Christine, Terreehorst, Ingrid, Newlands, Amy, Beerahee, Misba, Fokkens, Wytske, Tsitoura, Daphne C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
Soggetti:
Pharmacodynamics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004398/
https://ncbi.nlm.nih.gov/pubmed/23909699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12219
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