Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig

BACKGROUND AND PURPOSE: Nasal sensory nerves play an important role in symptoms associated with rhinitis triggered by environmental stimuli. Here, we propose that TRPV1 is pivotal in nasal sensory nerve activation and assess the potential of SB-705498 as an intranasal therapy for rhinitis. EXPERIMEN...

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Autores principales: Changani, Kumar, Hotee, Sarah, Campbell, Simon, Pindoria, Kashmira, Dinnewell, Laura, Saklatvala, Paula, Thompson, Sally-Anne, Coe, Diane, Biggadike, Keith, Vitulli, Giovanni, Lines, Marion, Busza, Albert, Denyer, Jane
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682706/
https://ncbi.nlm.nih.gov/pubmed/23441756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12145
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