Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1α (HP1α) with Heterochromatin

Protein tyrosine phosphorylation regulates a wide range of cellular processes at the plasma membrane. Recently, we showed that nuclear tyrosine phosphorylation by Src family kinases (SFKs) induces chromatin structural changes. In this study, we identify KRAB-associated protein 1 (KAP1/TIF1β/TRIM28),...

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Bibliographische Detailangaben
Hauptverfasser: Kubota, Sho, Fukumoto, Yasunori, Aoyama, Kazumasa, Ishibashi, Kenichi, Yuki, Ryuzaburo, Morinaga, Takao, Honda, Takuya, Yamaguchi, Noritaka, Kuga, Takahisa, Tomonaga, Takeshi, Yamaguchi, Naoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682585/
https://ncbi.nlm.nih.gov/pubmed/23645696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437756
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