Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1α (HP1α) with Heterochromatin

Protein tyrosine phosphorylation regulates a wide range of cellular processes at the plasma membrane. Recently, we showed that nuclear tyrosine phosphorylation by Src family kinases (SFKs) induces chromatin structural changes. In this study, we identify KRAB-associated protein 1 (KAP1/TIF1β/TRIM28),...

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Autors principals: Kubota, Sho, Fukumoto, Yasunori, Aoyama, Kazumasa, Ishibashi, Kenichi, Yuki, Ryuzaburo, Morinaga, Takao, Honda, Takuya, Yamaguchi, Noritaka, Kuga, Takahisa, Tomonaga, Takeshi, Yamaguchi, Naoto
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682585/
https://ncbi.nlm.nih.gov/pubmed/23645696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437756
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