Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease

The ATP-dependent Clp protease (ClpP) plays an essential role not only in the control of protein quality but also in the regulation of bacterial pathogen virulence, making it an attractive target for antibacterial treatment. We have previously determined the crystal structures of Staphylococcus aure...

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Autori principali: Ye, Fei, Zhang, Jie, Liu, Hongchuan, Hilgenfeld, Rolf, Zhang, Ruihan, Kong, Xiangqian, Li, Lianchun, Lu, Junyan, Zhang, Xinlei, Li, Donghai, Jiang, Hualiang, Yang, Cai-Guang, Luo, Cheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Computational Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682565/
https://ncbi.nlm.nih.gov/pubmed/23625918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.452714
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