Inactivation of JAK2/STAT3 Signaling Axis and Downregulation of M1 mAChR Cause Cognitive Impairment in klotho Mutant Mice, a Genetic Model of Aging

We previously reported cognitive dysfunction in klotho mutant mice. In the present study, we further examined novel mechanisms involved in cognitive impairment in these mice. Significantly decreased janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3) phosphorylation w...

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Hlavní autoři: Park, Seok-Joo, Shin, Eun-Joo, Min, Sun Seek, An, Jihua, Li, Zhengyi, Hee Chung, Yoon, Hoon Jeong, Ji, Bach, Jae-Hyung, Nah, Seung-Yeol, Kim, Won-Ki, Jang, Choon-Gon, Kim, Yong-Sun, Nabeshima, Yo-ichi, Nabeshima, Toshitaka, Kim, Hyoung-Chun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682136/
https://ncbi.nlm.nih.gov/pubmed/23389690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.39
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