Inactivation of JAK2/STAT3 Signaling Axis and Downregulation of M1 mAChR Cause Cognitive Impairment in klotho Mutant Mice, a Genetic Model of Aging

We previously reported cognitive dysfunction in klotho mutant mice. In the present study, we further examined novel mechanisms involved in cognitive impairment in these mice. Significantly decreased janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3) phosphorylation w...

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Bibliographic Details
Main Authors: Park, Seok-Joo, Shin, Eun-Joo, Min, Sun Seek, An, Jihua, Li, Zhengyi, Hee Chung, Yoon, Hoon Jeong, Ji, Bach, Jae-Hyung, Nah, Seung-Yeol, Kim, Won-Ki, Jang, Choon-Gon, Kim, Yong-Sun, Nabeshima, Yo-ichi, Nabeshima, Toshitaka, Kim, Hyoung-Chun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682136/
https://ncbi.nlm.nih.gov/pubmed/23389690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.39
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