Inactivation of JAK2/STAT3 Signaling Axis and Downregulation of M1 mAChR Cause Cognitive Impairment in klotho Mutant Mice, a Genetic Model of Aging

We previously reported cognitive dysfunction in klotho mutant mice. In the present study, we further examined novel mechanisms involved in cognitive impairment in these mice. Significantly decreased janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3) phosphorylation w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Park, Seok-Joo, Shin, Eun-Joo, Min, Sun Seek, An, Jihua, Li, Zhengyi, Hee Chung, Yoon, Hoon Jeong, Ji, Bach, Jae-Hyung, Nah, Seung-Yeol, Kim, Won-Ki, Jang, Choon-Gon, Kim, Yong-Sun, Nabeshima, Yo-ichi, Nabeshima, Toshitaka, Kim, Hyoung-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682136/
https://ncbi.nlm.nih.gov/pubmed/23389690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.39
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados