Melatonin Attenuates Memory Impairment Induced by Klotho Gene Deficiency Via Interactive Signaling Between MT2 Receptor, ERK, and Nrf2-Related Antioxidant Potential

BACKGROUND: We demonstrated that oxidative stress plays a crucial role in cognitive impairment in klotho mutant mice, a genetic model of aging. Since down-regulation of melatonin due to aging is well documented, we used this genetic model to determine whether the antioxidant property of melatonin af...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Shin, Eun-Joo, Chung, Yoon Hee, Le, Hoang-Lan Thi, Jeong, Ji Hoon, Dang, Duy-Khanh, Nam, Yunsung, Wie, Myung Bok, Nah, Seung-Yeol, Nabeshima, Yo-Ichi, Nabeshima, Toshitaka, Kim, Hyoung-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438546/
https://ncbi.nlm.nih.gov/pubmed/25550330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyu105
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados