Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

BACKGROUND: Activation of NADPH oxidase (PHOX) plays a critical role in mediating dopaminergic neuroinflammation. In the present study, we investigated the role of PHOX in methamphetamine (MA)-induced neurotoxic and inflammatory changes in mice. METHODS: We examined changes in mitogen-activated prot...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Dang, Duy-Khanh, Shin, Eun-Joo, Nam, Yunsung, Ryoo, Sungwoo, Jeong, Ji Hoon, Jang, Choon-Gon, Nabeshima, Toshitaka, Hong, Jau-Shyong, Kim, Hyoung-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717833/
https://ncbi.nlm.nih.gov/pubmed/26780950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0478-x
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