Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Wnt/β-catenin signaling is critically involved in metazoan development, stem cell maintenance and human disease. Using Xenopus laevis egg extract to screen for compounds that both stabilize Axin and promote β-catenin turnover, we identified an FDA-approved drug, pyrvinium, as a potent inhibitor of W...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Thorne, Curtis A, Hanson, Alison J, Schneider, Judsen, Tahinci, Emilios, Orton, Darren, Cselenyi, Christopher S, Jernigan, Kristin K, Meyers, Kelly C, Hang, Brian I, Waterson, Alex G, Kim, Kwangho, Melancon, Bruce, Ghidu, Victor P, Sulikowski, Gary A, LaFleur, Bonnie, Salic, Adrian, Lee, Laura A, Miller, David M, Lee, Ethan
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681608/
https://ncbi.nlm.nih.gov/pubmed/20890287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.453
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires