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Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
Wnt/β-catenin signaling is critically involved in metazoan development, stem cell maintenance and human disease. Using Xenopus laevis egg extract to screen for compounds that both stabilize Axin and promote β-catenin turnover, we identified an FDA-approved drug, pyrvinium, as a potent inhibitor of W...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3681608/ https://ncbi.nlm.nih.gov/pubmed/20890287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.453 |
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