Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Wnt/β-catenin signaling is critically involved in metazoan development, stem cell maintenance and human disease. Using Xenopus laevis egg extract to screen for compounds that both stabilize Axin and promote β-catenin turnover, we identified an FDA-approved drug, pyrvinium, as a potent inhibitor of W...

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Main Authors: Thorne, Curtis A, Hanson, Alison J, Schneider, Judsen, Tahinci, Emilios, Orton, Darren, Cselenyi, Christopher S, Jernigan, Kristin K, Meyers, Kelly C, Hang, Brian I, Waterson, Alex G, Kim, Kwangho, Melancon, Bruce, Ghidu, Victor P, Sulikowski, Gary A, LaFleur, Bonnie, Salic, Adrian, Lee, Laura A, Miller, David M, Lee, Ethan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681608/
https://ncbi.nlm.nih.gov/pubmed/20890287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.453
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