A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.
Cultured NIH-3T3 cells devoid of endogenous epidermal growth factor (EGF) receptors were transfected with cDNA expression constructs encoding either normal human EGF receptor or a receptor mutated in vitro at Lys-721, a residue that is thought to function as part of the ATP-binding site of the kinas...
محفوظ في:
| الحاوية / القاعدة: | Mol Cell Biol |
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| المؤلفون الرئيسيون: | , , , , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Taylor & Francis
1987
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3501826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.12.4568-4571.1987 |
| الوسوم: |
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