A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

Cultured NIH-3T3 cells devoid of endogenous epidermal growth factor (EGF) receptors were transfected with cDNA expression constructs encoding either normal human EGF receptor or a receptor mutated in vitro at Lys-721, a residue that is thought to function as part of the ATP-binding site of the kinas...

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Bibliographic Details
Main Authors: Honegger, A M, Szapary, D, Schmidt, A, Lyall, R, Van Obberghen, E, Dull, T J, Ullrich, A, Schlessinger, J
Format: Artigo
Language:Inglês
Published: 1987
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC368145/
https://ncbi.nlm.nih.gov/pubmed/3501826
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