A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

Cultured NIH-3T3 cells devoid of endogenous epidermal growth factor (EGF) receptors were transfected with cDNA expression constructs encoding either normal human EGF receptor or a receptor mutated in vitro at Lys-721, a residue that is thought to function as part of the ATP-binding site of the kinas...

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Publicat a:	Mol Cell Biol
Autors principals:	Honegger, A M, Szapary, D, Schmidt, A, Lyall, R, Van Obberghen, E, Dull, T J, Ullrich, A, Schlessinger, J
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 1987
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3501826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.12.4568-4571.1987
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