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RBC-coupled tPA Prevents Impairment of Cerebral Vasodilatory Responses Through Inhibition of JNK and Potentiation of p38 MAPK after Cerebral Photothrombosis in the Newborn Pig

OBJECTIVE: Pediatric ischemic stroke is a poorly understood, yet clinically important, problem. The sole approved treatment for acute stroke is tissue type plasminogen activator (tPA). However, tPA vasoactivity aggravates hypoxia/ischemia (H/I)-induced impairment of cerebrovasodilation in response t...

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Bibliografiske detaljer
Main Authors: Armstead, William M., Ganguly, Kumkum, Riley, John, Kiessling, J. Willis, Cines, Douglas B., Higazi, Abd AR., Zaitsev, Sergei, Muzykantov, Vladimir R.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681424/
https://ncbi.nlm.nih.gov/pubmed/21037505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PCC.0b013e3181fe40a7
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