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RBC-coupled tPA Prevents Impairment of Cerebral Vasodilatory Responses Through Inhibition of JNK and Potentiation of p38 MAPK after Cerebral Photothrombosis in the Newborn Pig
OBJECTIVE: Pediatric ischemic stroke is a poorly understood, yet clinically important, problem. The sole approved treatment for acute stroke is tissue type plasminogen activator (tPA). However, tPA vasoactivity aggravates hypoxia/ischemia (H/I)-induced impairment of cerebrovasodilation in response t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3681424/ https://ncbi.nlm.nih.gov/pubmed/21037505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PCC.0b013e3181fe40a7 |
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