RBC-coupled tPA Prevents Impairment of Cerebral Vasodilatory Responses and Tissue Injury In Pediatric Cerebral Hypoxia/Ischemia Through Inhibition of ERK MAPK Activation

Babies experience hypoxia (H) and ischemia (I) from stroke. The only approved treatment for stroke is fibrinolytic therapy with tissue-type plasminogen activator (tPA). However, tPA potentiates H/I-induced impairment of responses to cerebrovasodilators such as hypercapnia and hypotension, and blocka...

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Autori principali: Armstead, William M, Ganguly, Kumkum, Kiessling, J W, Chen, Xiao-Han, Smith, Douglas H, Higazi, Abd AR, Cines, Douglas B, Bdeir, Khalil, Zaitsev, Sergei, Muzykantov, Vladimir R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719676/
https://ncbi.nlm.nih.gov/pubmed/19436314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.61
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