Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice

We investigated the relationship among oxidative stress, hypertension, renal injury, and angiotensin-converting enzyme-2 (ACE2) expression in type 1 diabetic Akita mice. Blood glucose, blood pressure, and albuminuria were monitored for up to 5 mo in adult male Akita and Akita catalase (Cat) transgen...

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Hauptverfasser: Shi, Yixuan, Lo, Chao-Sheng, Chenier, Isabelle, Maachi, Hasna, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680689/
https://ncbi.nlm.nih.gov/pubmed/23552863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00405.2012
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