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Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance.

A clonal cell line (56-42) that was stably and exclusively resistant to the toxic effects of the antileukemic agent 5-aza-2'-deoxycytidine (5-aza-CdR) was derived from C3H 10T1/2 C18 cells after multiple treatments with 5-aza-CdR. The 50% lethal dose of 5-aza-CdR for these cells was 1.3 microM,...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Michalowsky, L A, Jones, P A
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1987
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367939/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2444874/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.9.3076
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