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S110, a 5-aza-2’-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

Methylation of CpG islands in promoter regions is often associated with gene silencing and aberrant DNA methylation occurs in most cancers, leading to the silencing of some tumor suppressor genes. Reversal of this abnormal hypermethylation by DNA methylation inhibitors is effective in re-activating...

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書誌詳細
主要な著者: Chuang, Jody C., Warner, Steven L., Vollmer, David, Vankayalapati, Hariprasad, Redkar, Sanjeev, Bearss, David J., Qiu, Xiangning, Yoo, Christine B., Jones, Peter A.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868087/
https://ncbi.nlm.nih.gov/pubmed/20442312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1048
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