S110, a 5-aza-2’-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

Methylation of CpG islands in promoter regions is often associated with gene silencing and aberrant DNA methylation occurs in most cancers, leading to the silencing of some tumor suppressor genes. Reversal of this abnormal hypermethylation by DNA methylation inhibitors is effective in re-activating...

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Huvudupphovsmän: Chuang, Jody C., Warner, Steven L., Vollmer, David, Vankayalapati, Hariprasad, Redkar, Sanjeev, Bearss, David J., Qiu, Xiangning, Yoo, Christine B., Jones, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868087/
https://ncbi.nlm.nih.gov/pubmed/20442312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1048
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