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Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance.

A clonal cell line (56-42) that was stably and exclusively resistant to the toxic effects of the antileukemic agent 5-aza-2'-deoxycytidine (5-aza-CdR) was derived from C3H 10T1/2 C18 cells after multiple treatments with 5-aza-CdR. The 50% lethal dose of 5-aza-CdR for these cells was 1.3 microM,...

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Bibliografske podrobnosti
Main Authors: Michalowsky, L A, Jones, P A
Format: Artigo
Jezik:Inglês
Izdano: 1987
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC367939/
https://ncbi.nlm.nih.gov/pubmed/2444874
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