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The ASC/Caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia-reperfusion injury

Apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC), an adaptor protein for inflammasome receptors, is essential for inducing the caspase-1 activaton and the consequent secretion of IL-1β, which associates with local inflammation during liver ischemia...

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Detalhes bibliográficos
Main Authors: Kamo, Naoko, Ke, Bibo, Ghaffari, Amir A., Busuttil, Ronald W., Cheng, Genhong, Kupiec-Weglinski, Jerzy W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679353/
https://ncbi.nlm.nih.gov/pubmed/23408710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26320
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