Sotrastaurin, a Protein Kinase C Inhibitor, Ameliorates Ischemia and Reperfusion Injury in Rat Orthotopic Liver Transplantation

Sotraustaurin (STN), a small molecule, targeted PKC inhibitor that prevents T lymphocyte activation via a calcineurin-independent pathway, is currently tested in Phase II renal and liver transplantation clinical trials. We have documented the key role of activated T cells in the inflammation cascade...

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Detalles Bibliográficos
Autores principales: Kamo, Naoko, Shen, Xiu-da, Ke, Bibo, Busuttil, Ronald W., Kupiec-Weglinski, Jerzy W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625141/
https://ncbi.nlm.nih.gov/pubmed/21883905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03700.x
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