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THE BLOCKADE OF JANUS KINASE-2 (JAK2) SIGNALING AMELIORATES MOUSE LIVER DAMAGE DUE TO ISCHEMIA AND REPERFUSION

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is one of the major pathways for cytokine signal transduction. However, the role of the JAK/STAT pathway in liver I/R is not clear. This study focuses on JAK2, which functions upstream of STAT-1 in JAK/STAT, and...

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Autors principals: Freitas, Maria Cecilia S., Uchida, Yoichiro, Zhao, Danyun, Ke, Bibo, Busuttil, Ronald W., Kupiec-Weglinski, Jerzy W.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001321/
https://ncbi.nlm.nih.gov/pubmed/20440769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lt.22036
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