Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development

BACKGROUND: Prostate morphogenesis initiates in the urogenital sinus (UGS) with epithelial bud development. Sulfatase-1 (SULF1) inhibits bud development by reducing extracellular heparan sulfate (HS) 6-O sulfation and impairing FGF10 signaling via the ERK1/2 mitogen activated kinases. RESULTS: We ch...

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Main Authors: Buresh-Stiemke, Rita A., Malinowski, Rita L., Keil, Kimberly P., Vezina, Chad M., Oosterhof, Arie, van Kuppevelt, Toin H., Marker, Paul C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677568/
https://ncbi.nlm.nih.gov/pubmed/23074159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.23886
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