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A foreign dihydrofolate reductase gene in transgenic mice acts as a dominant mutation.
We have produced 17 lines of transgenic mice by microinjecting a full-length cDNA clone of an altered dihydrofolate reductase (dhfr) gene. The protein specified by this gene carries a point mutation which triples its Km for dihydrofolate and reduces substrate turnover 20-fold relative to the wild-ty...
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| Опубликовано в: : | Mol Cell Biol |
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| Главный автор: | |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
1986
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367756/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3785192/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.6.6.2158 |
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