Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

Most transient receptor potential (TRP) channels are regulated by phosphatidylinositol-4,5-biphosphate (PIP(2)), although the structural rearrangements occurring on PIP(2) binding are currently far from clear. Here we report that activation of the TRP vanilloid 4 (TRPV4) channel by hypotonic and hea...

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Detalhes bibliográficos
Main Authors: Garcia-Elias, Anna, Mrkonjić, Sanela, Pardo-Pastor, Carlos, Inada, Hitoshi, Hellmich, Ute A., Rubio-Moscardó, Fanny, Plata, Cristina, Gaudet, Rachelle, Vicente, Rubén, Valverde, Miguel A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677448/
https://ncbi.nlm.nih.gov/pubmed/23690576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220231110
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