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Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel

[Image: see text] The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeostasis. Recent studies reported that mutations in TRPV4, including some in its ankyrin repeat domain (ARD), are associated with h...

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Detalhes bibliográficos
Main Authors: Inada, Hitoshi, Procko, Erik, Sotomayor, Marcos, Gaudet, Rachelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413242/
https://ncbi.nlm.nih.gov/pubmed/22702953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300279b
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