Carcinogen-mediated methotrexate resistance and dihydrofolate reductase amplification in Chinese hamster cells.

We have investigated different parameters characterizing carcinogen-mediated enhancement of methotrexate resistance in Chinese hamster ovary (CHO) cells and in simian virus 40-transformed Chinese hamster embryo (C060) cells. We show that this enhancement reflects dihydrofolate reductase (dhfr) gene...

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izdano v:	Mol Cell Biol
Principais autores:	Kleinberger, T, Etkin, S, Lavi, S
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 1986
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3023913/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.6.6.1958-1964.1986
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