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A kinetic framework for tRNA ligase and enforcement of a 2′-phosphate requirement for ligation highlights the design logic of an RNA repair machine
tRNA ligases are essential components of informational and stress-response pathways entailing repair of RNA breaks with 2′,3′-cyclic phosphate and 5′-OH ends. Plant and fungal tRNA ligases comprise three catalytic domains. Phosphodiesterase and kinase modules heal the broken ends to generate the 3′-...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677281/ https://ncbi.nlm.nih.gov/pubmed/23515942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.038406.113 |
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