Proteolytic Activation Transforms Heparin Cofactor II into a Host Defense Molecule

The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remains enigmatic. In this study, we demonstrate a previously unknown role for HCII in host defense. Proteolytic cleav...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kalle, Martina, Papareddy, Praveen, Kasetty, Gopinath, Tollefsen, Douglas M., Malmsten, Martin, Mörgelin, Matthias, Schmidtchen, Artur
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: AAI 2013
Gaiak:
Infectious Disease and Host Response
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677170/
https://ncbi.nlm.nih.gov/pubmed/23656734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203030
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