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Proteolytic Activation Transforms Heparin Cofactor II into a Host Defense Molecule
The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remains enigmatic. In this study, we demonstrate a previously unknown role for HCII in host defense. Proteolytic cleav...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
AAI
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677170/ https://ncbi.nlm.nih.gov/pubmed/23656734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203030 |
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