Structure-activity relationships and mechanism of action of Eph-ephrin antagonists: interaction of cholanic acid with the EphA2 receptor

The Eph–ephrin system, including the EphA2 receptor and the ephrin-A1 ligand, plays a critical role in tumor and vascular functions during carcinogenesis. We previously identified (3α,5β)-3-hydroxycholan-24-oic acid (lithocholic acid) as an Eph-ephrin antagonist able to inhibit EphA2 receptor activa...

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Detalhes bibliográficos
Main Authors: Tognolini, Massimiliano, Incerti, Matteo, Mohamed, Iftiin Hassan, Giorgio, Carmine, Russo, Simonetta, Bruni, Renato, Lelli, Barbara, Bracci, Luisa, Noberini, Roberta, Pasquale, Elena B., Barocelli, Elisabetta, Vicini, Paola, Mor, Marco, Lodola, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677030/
https://ncbi.nlm.nih.gov/pubmed/22529030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200102
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