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Brain injury-induced proteolysis is reduced in a novel calpastatin overexpressing transgenic mouse

The calpain family of calcium-dependent proteases has been implicated in a variety of diseases and neurodegenerative pathologies. Prolonged activation of calpains results in proteolysis of numerous cellular substrates including cytoskeletal components and membrane receptors, contributing to cell dem...

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Библиографические подробности
Главные авторы: Schoch, Kathleen M., von Reyn, Catherine R., Bian, Jifeng, Telling, Glenn C., Meaney, David F., Saatman, Kathryn E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676438/
https://ncbi.nlm.nih.gov/pubmed/23305291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12144
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