Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury

Traumatic brain injury (TBI) results in abrupt, initial cell damage leading to delayed neuronal death. The calcium-activated proteases, calpains, are known to contribute to this secondary neurodegenerative cascade. Although the specific inhibitor of calpains, calpastatin, is present within neurons,...

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Bibliografiske detaljer
Main Authors: Schoch, Kathleen M., Evans, Heather N., Brelsfoard, Jennifer M., Madathil, Sindhu K., Takano, Jiro, Saido, Takaomi C., Saatman, Kathryn E.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392428/
https://ncbi.nlm.nih.gov/pubmed/22572592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.04.022
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