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Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G
APOBEC3G has an important role in human defense against retroviral pathogens, including HIV-1. Its single-stranded DNA cytosine deaminase activity, located in its C-terminal domain (A3Gctd), can mutate viral cDNA and restrict infectivity. We used time-resolved nuclear magnetic resonance (NMR) spectr...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3676121/ https://ncbi.nlm.nih.gov/pubmed/23596292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03173-12 |
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