Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

APOBEC3G has an important role in human defense against retroviral pathogens, including HIV-1. Its single-stranded DNA cytosine deaminase activity, located in its C-terminal domain (A3Gctd), can mutate viral cDNA and restrict infectivity. We used time-resolved nuclear magnetic resonance (NMR) spectr...

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Hlavní autoři: Harjes, Stefan, Solomon, William C., Li, Ming, Chen, Kuan-Ming, Harjes, Elena, Harris, Reuben S., Matsuo, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676121/
https://ncbi.nlm.nih.gov/pubmed/23596292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03173-12
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