Inhibition of Hepatitis C Virus (HCV) Replication by Specific RNA Aptamers against HCV NS5B RNA Replicase

This study identified specific and avid RNA aptamers consisting of 2′-hydroxyl- or 2′-fluoropyrimidines against hepatitis C virus (HCV) NS5B replicase, an enzyme that is essential for HCV replication. These aptamers acted as potent decoys to competitively impede replicase-catalyzed RNA synthesis act...

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Hlavní autoři: Lee, Chang Ho, Lee, Young Ju, Kim, Ji Hyun, Lim, Jong Hoon, Kim, Jung-Hye, Han, Wonkyo, Lee, Soo-Han, Noh, Gyu-Jeong, Lee, Seong-Wook
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676086/
https://ncbi.nlm.nih.gov/pubmed/23596299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00405-13
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