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Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro

Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a m...

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Detalhes bibliográficos
Main Authors: Yang, Wengang, Sun, Yongnian, Phadke, Avinash, Deshpande, Milind, Huang, Mingjun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797658/
https://ncbi.nlm.nih.gov/pubmed/17088480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00498-06
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