Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors

We have discovered a novel class of compounds active against hepatitis C virus (HCV), using a surrogate cellular system, HCV replicon cells. The leading compound in the series, ACH-806 (GS-9132), is a potent and specific inhibitor of HCV. The selection of resistance replicon variants against ACH-806...

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Autori principali: Yang, Wengang, Zhao, Yongsen, Fabrycki, Joanne, Hou, Xiaohong, Nie, Xingtie, Sanchez, Amy, Phadke, Avinash, Deshpande, Milind, Agarwal, Atul, Huang, Mingjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415816/
https://ncbi.nlm.nih.gov/pubmed/18411324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01548-07
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