Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus

Hepatitis C virus (HCV)-encoded nonstructural protein 3 (NS3) possesses protease, NTPase, and helicase activities, which are considered essential for viral proliferation. Thus, HCV NS3 is a good putative therapeutic target protein for the development of anti-HCV agents. In this study, we isolated sp...

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Main Authors: HWANG, BYOUNGHOON, CHO, JUNG SUN, YEO, HYEON JU, KIM, JUNG-HYE, CHUNG, KYUNG MIN, HAN, KYUNGSOOK, JANG, SUNG KEY, LEE, SEONG-WOOK
Format: Artigo
Sprog:Inglês
Udgivet: Copyright 2004 by RNA Society 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370617/
https://ncbi.nlm.nih.gov/pubmed/15247433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7100904
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