Inhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected Cells

We describe here the further characterization of two DNA aptamers that specifically bind to hepatitis C virus (HCV) RNA polymerase (NS5B) and inhibit its polymerase activity in vitro. Although they were obtained from the same selection procedure and contain an 11-nucleotide consensus sequence, our r...

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Bibliographic Details
Main Authors: Bellecave, Pantxika, Cazenave, Christian, Rumi, Julie, Staedel, Cathy, Cosnefroy, Ophélie, Andreola, Marie-Line, Ventura, Michel, Tarrago-Litvak, Laura, Astier-Gin, Thérèse
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415787/
https://ncbi.nlm.nih.gov/pubmed/18347106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01227-07
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