Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

Hepatitis C virus (HCV) is the major cause of progressive liver disease such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Previously, we reported that a 29 nucleotide-long 2'-F pyrimidine modified RNA aptamer against the HCV nonstructural protein 5B efficiently inhibited HCV r...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Principais autores: Lee, Chang Ho, Lee, Soo-Han, Kim, Ji Hyun, Noh, Yook-Hwan, Noh, Gyu-Jeong, Lee, Seong-Wook
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881758/
https://ncbi.nlm.nih.gov/pubmed/26440598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.30
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