miRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection

Thymic epithelial cells provide unique cues for the life-long selection and differentiation of a repertoire of functionally diverse T cells. Rendered miRNA deficient, these stromal cells in the mouse lose their capacity to instruct the commitment of haematopoietic precursors to a T cell fate, to eff...

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Hauptverfasser: Zuklys, Saulius, Mayer, Carlos E., Zhanybekova, Saule, Stefanski, Heather E., Nusspaumer, Gretel, Gill, Jason, Barthlott, Thomas, Chappaz, Stephane, Nitta, Takeshi, Dooley, James, Nogales-Cadenas, Ruben, Takahama, Yousuke, Finke, Daniela, Liston, Adrian, Blazar, Bruce R., Pascual-Montano, Alberto, Holländer, Georg A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675876/
https://ncbi.nlm.nih.gov/pubmed/22972926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200783
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