Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

Calcium-dependent protein kinases (CDPKs) play pivotal roles in the calcium-signaling pathway in plants, ciliates and apicomplexan parasites, and comprise a CaMK-like kinase domain regulated by a calcium-binding domain in the C-terminus. To understand this intramolecular mechanism of activation, we...

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Main Authors: Wernimont, Amy K., Artz, Jennifer D., Finerty, Patrick, Lin, Y., Amani, Mehrnaz, Allali-Hassani, Abdellah, Senisterra, Guillermo, Vedadi, Masoud, Tempel, Wolfram, Mackenzie, Farrell, Chau, Irene, Lourido, Sebastian, Sibley, L. David, Hui, Raymond
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675764/
https://ncbi.nlm.nih.gov/pubmed/20436473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1795
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