Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY

Human choline kinase (ChoK) catalyzes the first reaction in phosphatidylcholine biosynthesis and exists as ChoKα (α1 and α2) and ChoKβ isoforms. Recent studies suggest that ChoK is implicated in tumorigenesis and emerging as an attractive target for anticancer chemotherapy. To extend our understandi...

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Hlavní autoři: Hong, Bum Soo, Allali-Hassani, Abdellah, Tempel, Wolfram, Finerty, Patrick J., MacKenzie, Farrell, Dimov, Svetoslav, Vedadi, Masoud, Park, Hee-Won
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871500/
https://ncbi.nlm.nih.gov/pubmed/20299452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039024
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