Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY

Human choline kinase (ChoK) catalyzes the first reaction in phosphatidylcholine biosynthesis and exists as ChoKα (α1 and α2) and ChoKβ isoforms. Recent studies suggest that ChoK is implicated in tumorigenesis and emerging as an attractive target for anticancer chemotherapy. To extend our understandi...

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Detalhes bibliográficos
Main Authors: Hong, Bum Soo, Allali-Hassani, Abdellah, Tempel, Wolfram, Finerty, Patrick J., MacKenzie, Farrell, Dimov, Svetoslav, Vedadi, Masoud, Park, Hee-Won
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871500/
https://ncbi.nlm.nih.gov/pubmed/20299452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039024
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