Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

We present active-state structures of the G protein-coupled receptor (GPCRs) rhodopsin carrying the disease-causing mutation G90D. Mutations of G90 cause either retinitis pigmentosa (RP) or congenital stationary night blindness (CSNB), a milder, non-progressive form of RP. Our analysis shows that th...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Singhal, Ankita, Ostermaier, Martin K, Vishnivetskiy, Sergey A, Panneels, Valérie, Homan, Kristoff T, Tesmer, John J G, Veprintsev, Dmitry, Deupi, Xavier, Gurevich, Vsevolod V, Schertler, Gebhard F X, Standfuss, Joerg
Natura: Artigo
Lingua:Inglês
Pubblicazione: European Molecular Biology Organization 2013
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674435/
https://ncbi.nlm.nih.gov/pubmed/23579341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.44
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi