Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

We present active-state structures of the G protein-coupled receptor (GPCRs) rhodopsin carrying the disease-causing mutation G90D. Mutations of G90 cause either retinitis pigmentosa (RP) or congenital stationary night blindness (CSNB), a milder, non-progressive form of RP. Our analysis shows that th...

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Hlavní autoři: Singhal, Ankita, Ostermaier, Martin K, Vishnivetskiy, Sergey A, Panneels, Valérie, Homan, Kristoff T, Tesmer, John J G, Veprintsev, Dmitry, Deupi, Xavier, Gurevich, Vsevolod V, Schertler, Gebhard F X, Standfuss, Joerg
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674435/
https://ncbi.nlm.nih.gov/pubmed/23579341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.44
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